Pharmacodynamics

Biotrial’s experience covers the following areas:

 

Biological markers:

• Hormones: prolactin, cortisol, ACTH, FSH, LH, estradiol, progesterone, insulin, C peptide
• Cardiovascular: active renin, vasopressin, aldosterone, angiotensin
• CNS: DHPG, MAO-B activity in platelets, 5 HT levels in platelets
• Immunology: ANA, ASMA, ALKM, CD4, CD8 cryopreservation for immunophenotype
• Lipids: Lp(a), Apo A, Apo B, Apo C3, Cholesterol HDL subclasses
• etc.

Central Nervous System: 

• Electrophysiology: spectral analysis of resting and sleep EEG (polysomnography), event related evoked potentials
• Polysomnography
• Neurology clinical examinations
• Psychomotor performance: tracking, actimetry, body sway, tapping 
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• Attention/vigilance: CFF, CRT, CPT...
• Memory : learning memory task, free recall, word stem completion, tower of Hanoi/Toronto, Sternberg memory scanning task, Buschke selective reminding task, digit span forwards/backwards..
• Information processing: rapid visual information processing, DSST
• Anxiety models: Stroop test, delayed auditory feedback, LOGAN procedure, fixed interval test
• Subjective evaluation: ARCI, profile of mood scales, Stanford sleepiness scale, sleep questionnaire, Spielberger anxiety inventory
• Neuroimaging: PET scan
• etc.

Cardiovascular pharmacology:

• Cardiac monitoring
• ECG and blood pressure recording, 24 hour Holter
• ECG expertise
• ECG manual reading ( QT, QTc, QT dispersion)
• Maximal and submaximal exercise test (HR, BP, ST, QT, VO2max)
• Blood pressure: Dinamap, ABPM
• Echodoppler
• Echocardiography
• Systolic time interval
• Impedance cardiography
• Telemetry
• ECG Central Lab
• etc.

Dermatology

• Skin perfusion: Laser Scanner Doppler (LSD)
• Hyperfused Area skin surface: Videocapillaroscopy
• Skin colorimetry: Chromametry
• Psoriasis Skin Severity Index (PASI)
• Body Surface Area (BSA)
• Overall Lesion severity (OLS)
• Dermatology Life Quality Index (DLQI) questionnaire
• Pin prick test
• etc.

Gastroenterology function tests:

• 24h oesophageal and gastric pH recording
• Oesophageal, colic and rectal manometric recording of pressure and motility
• Oesophageal, gastric, colic and rectal tone and sensitivity (barostat) recording
• Pentagastrine test
• Gastric emptying (SPECT)
• etc.

Haemostasis & Haematology 

• Coagulation and Platelet Biomarkers for PK/PD safety: Ecarine clotting time (ECT),aPTT, TT, INR, anti Xa or IIa activity, residual thrombin activity
• F1+2, TAT, TFPI, PAI, tPA, bTG, PF4. ( Enzymo-Immuno Assays, Stago, Bipool platelet aggregation (collagen, U46619, ADP arachidonic acid)
• Thrombin Generation Test, Rotem
• Flow cytometry: extra and intra cellular typing
• Platelet aggregation with agregometry ( Helena PAP8 Biodis) and flow cytometry (FC500 Beckman, Facscalibur Becton Dickinson
• etc.

Imaging:

• SPECT (CBF)
• PET (FDG, C11 in progress)
• MRI
• Echo doppler
• Stereotaxic Biopsy
• etc.

Ophthalmology examinations:

• Visual acuity
• Electrooculogram
• Electroretinogram
• Visual evoked potentials
• Humphrey visual field
• Farnsworth-100 Hue colour test
• Slit lamp test
• Photostress test
• Pupil size
• Saccadic eye movement
• Tonometry
• Amsler grid
• etc.

Respiratory function tests:

• Spirometry
• Peak Flow ( FEV1)
• Plethysmography
• Bronchodilator reversibility
• Histamine challenge
• etc.

Renal function assessment:

• Renal plasma flow rate
• Glomerular filtration flow rate
• Urinary output
• Free water clearance
• Urinary sodium excretion
• Renal tubular function (lithium clearance)
• Osmolality
• etc.

For more information please contact us:
contact@biotrial.com