Safety Pharmacology

Core Battery Studies

• Central Nervous System
  • Effects on general behaviour and body temperature
  • Effects on motor activity
  • Effects on motor coordination
  • Effects on convulsive threshold
  • Effects on vigilance
     
• Cardiovascular System
  • Cardiovascular profile:
    Systemic Blood Pressure, Pulmonary Arterial Pressure, Atrial Pressure, Heart Rate, Myocardial Contractility, Cardiac output, Stroke Volume, Total Peripheral Resistance, Peripheral Blood Flows (coronary, carotid, femoral, renal…), Vascular Resistances, Myocardial Oxygen Consumption, Blood Gas Analysis, ECG (PR, QRS, QT, QTc).

• Respiratory System
  • Whole-Body Plethysmography

Supplemental Studies

• Gastrointestinal System
  • Gastric emptying
  • Gastrointestinal motility 
     
• Renal System
  • Diuresis
  • Electrolytes excretion
  • Creatinine Clearance

Follow-up Studies

• Abuse potential / drug dependence
• Hyperalgesic / pronociceptive potential
• Amnesic potential 
• Orthostatic hypotension
• Proarrhythmic potential
• Haemorrhagic risk
• Prothrombotic potential
• Airway resistance
• Proallergenic potential
• Biological markers

For more information please contact us:
contact@biotrial.com