Pharmacodynamics

Biotrial’s experience includes, but is not limited to, the following areas:

Cardiovascular Pharmacology

  • 12 lead digital ECG recording (Rest & Exercise)
  • 3-lead and 12-lead Holter ECG
  • ECG Monitor / Telemetry
  • Blood pressure (Dinamap, ABPM)
  • Measurement of cardiac output (Systolic Time Intervals, Impedance, Echocardiography)
  • Echodoppler
  • ECG Core Lab

Dermatology

  • Skin perfusion: Laser Scanner Doppler (LSD)
  • Hyperfused Area skin surface
  • Skin colorimetry: Chromametry
  • Psoriasis Skin Severity Index (PASI)
  • Overall Lesion severity (OLS)

Endocrinology / Metabolism

  • Glucose Clamp technique
  • Oral glucose tolerance test
  • Calorimetry
  • Bioelectrical Impedance analysis
  • Ad libitum caloric intake
  • Waist circumference
  • Weight

Gastroenterology Function Tests

  • 24h oesophageal and gastric pH recording
  • Oesophageal, colic and rectal manometric recording of pressure and motility
  • Oesophageal, gastric, colic and rectal tone and sensitivity (barostat) recording
  • Pentagastrine test
  • Gastric emptying (SPECT)

Imaging

  • SPECT (CBF)
  • PET (FDG, C11)
  • fMRI
  • Echo doppler
  • Stereotaxic Biopsy

Ophthalmology Examinations

  • Visual acuity
  • Electrooculogram
  • Electroretinogram
  • Visual evoked potentials
  • Humphrey visual field
  • Farnsworth-100 Hue colour test
  • Slit lamp test
  • Photostress test
  • Pupil size
  • Saccadic eye movement
  • Tonometry
  • Amsler grid

Respiratory Function Tests

  • Spirometry (FEV, PEV, PEFT) including reversibility testing
  • Allergen challenge
  • Skin prick test

Renal Function Assessment

  • Renal plasma flow rate
  • Glomerular filtration flow rate
  • Urinary output
  • Free water clearance
  • Urinary sodium excretion
  • Renal tubular function (lithium clearance)
  • Osmolality

Biological Markers

Biotrial offers more than 400 biological markers in various areas including:

  • Hormones
  • Cardiovascular
  • CNS
  • Immunology
  • Lipids
  • Hemostasis
  • Haematology

 

For more information please contact us: contact@biotrial.com