Safety Pharmacology

Guinea-Pig Early Cardiovascular De-Risking

  • Anaesthetised and telemetered guinea-Pig
  • Rapid screening format for early detection of QT prolongation and other CV issues

Core Battery


CNS
  • Irwin Test / Functional Observational Battery
    • Rodents and large animals
    • We can adapt the test to your in-house protocol
  • Motor co-ordination
    • Rota-rod in rat and mouse
  • Convulsion threshold
    • Intravenous PTZ test

Cardiovascular

  • Anaesthetised and Telemetry models.
  • Rodents and large animals
  • Multi-frequency telemetry recording in pair-housed animals
  • High quality ECG in chronically-instrumented animals

Respiratory

  • Whole-body plethysmography in mouse, rat and guinea-pig
    (IV route of administration possible).

Supplemental Studies

 

  • Gastrointestinal System 
    • Gastric emptying
    • Gastrointestinal motility
  • Renal System
    • Diuresis
    • Electrolytes excretion
    • Creatinine Clearance

Orthostatic hypotension in telemetered animals (‘tilt test’)

Biomarkers

 

  • Troponin I
    • Correlation with extent of cardiac lesions

 

  • Kidney Toxicity
    • Panel of biomarkers providing early indication of toxicity.

 

Biotrial’s strengths:
  • Excellent quality as proven by high levels of repeat business
  • Fast and flexible
  • Competitively priced
  • Reports excellently written, requiring minimal proof-reading time

 

For more information please contact us: contact@biotrial.com

 

Scientific Publications