{"id":7951,"date":"2023-02-07T13:39:15","date_gmt":"2023-02-07T13:39:15","guid":{"rendered":"https:\/\/www.biotrial.com?page_id=7951"},"modified":"2024-11-21T13:41:46","modified_gmt":"2024-11-21T13:41:46","slug":"efficacite","status":"publish","type":"page","link":"https:\/\/www.biotrial.com\/fr-ca\/solutions-services\/preclinique\/efficacite\/","title":{"rendered":"Efficacit\u00e9"},"content":{"rendered":"\n    <section class=\"acf anchors-depth-3 positionStickyElement\" id=\"\">\n        <div class=\"container\">\n            <div class=\"left\">\n                                    <a href=\"https:\/\/www.biotrial.com\/fr-ca\/solutions-services\/preclinique\/\" class=\"link return\">Retour<\/a>\n                            <\/div>\n            <div class=\"right\">\n                                    <a class=\"anchor\" href=\"#blockResources\">\n                        <span>Ressources<\/span>\n                    <\/a>\n                                    <a class=\"anchor\" href=\"#blockInformation\">\n                        <span>D\u00e9couvrir \u00e9galement<\/span>\n                    <\/a>\n                            <\/div>\n        <\/div>\n    <\/section>\n\n\n\n<section class=\"acf header-depth-3\" id=\"\">\n    <div class=\"container large\">\n                    <div class=\"container\">\n                <div class=\"content\">\n                                            <h1>Efficacit\u00e9 des m\u00e9dicaments dans les \u00e9tudes pr\u00e9cliniques<\/h1>\n                                                                <p>Dans les \u00e9tudes pr\u00e9cliniques, les mod\u00e8les utilis\u00e9s pour \u00e9tudier les pathologies doivent pr\u00e9senter des caract\u00e9ristiques comparables aux conditions observ\u00e9es chez l\u2019homme. Les mod\u00e8les animaux exp\u00e9rimentaux sont donc pr\u00e9cieux pour une meilleure compr\u00e9hension des m\u00e9canismes pathologiques et pour \u00e9valuer<strong> l\u2019efficacit\u00e9 th\u00e9rapeutique des nouveaux m\u00e9dicaments<\/strong>, notamment gr\u00e2ce \u00e0 :<\/p>\n<ul data-sourcepos=\"9:1-12:0\">\n<li><strong>Des mod\u00e8les valid\u00e9s <\/strong>pour diff\u00e9rents domaines th\u00e9rapeutiques, comme l\u2019oncologie, les troubles du syst\u00e8me nerveux central,\u00a0de l\u2019h\u00e9mostase, les fonctions cardiovasculaires et respiratoires ainsi que r\u00e9nales et gastro-intestinales.<\/li>\n<li>Une expertise couvrant une <strong>vari\u00e9t\u00e9 de mod\u00e8les pr\u00e9cliniques<\/strong> et de <strong>m\u00e9thodologies pour \u00e9valuer l\u2019efficacit\u00e9<\/strong> des mol\u00e9cules<strong>.<\/strong><\/li>\n<li><strong>Une \u00e9quipe de scientifiques<\/strong> qui travaille en \u00e9troite collaboration avec vous \u00e0 chaque \u00e9tape du processus de d\u00e9couverte et de d\u00e9veloppement du m\u00e9dicament pour s\u00e9lectionner la meilleure approche pour votre \u00e9tude sp\u00e9cifique.<\/li>\n<\/ul>\n<p>Biotrial s&#8217;engage \u00e0 fournir des donn\u00e9es fiables et des rapports clairs pour vous aider \u00e0 prendre des d\u00e9cisions concernant le d\u00e9veloppement de vos mol\u00e9cules.<\/p>\n\n                                    <\/div>\n            <\/div>\n                            <picture>\n                <source type=\"image\/webp\"\n                    srcset=\"https:\/\/www.biotrial.com\/app\/uploads\/2023\/05\/2211023-biotrial-pdv-reportage-01-187-1-1060x400.webp, https:\/\/www.biotrial.com\/app\/uploads\/2023\/05\/2211023-biotrial-pdv-reportage-01-187-1-1060x400@2x.webp 2x\">\n                <source type=\"image\/jpeg\"\n                    srcset=\"https:\/\/www.biotrial.com\/app\/uploads\/2023\/05\/2211023-biotrial-pdv-reportage-01-187-1-1060x400.jpg, https:\/\/www.biotrial.com\/app\/uploads\/2023\/05\/2211023-biotrial-pdv-reportage-01-187-1-1060x400@2x.jpg 2x\">\n                <img decoding=\"async\" src=\"https:\/\/www.biotrial.com\/app\/uploads\/2023\/05\/2211023-biotrial-pdv-reportage-01-187-1-1060x400.jpg\" alt=\"\"\n                    width=\"1060\" height=\"400\" loading=\"lazy\" \/>\n            <\/picture>\n            <\/div>\n<\/section>\n\n<div class=\"core core-columns\" ><div class=\"container\">\n<div class=\"wp-block-columns are-vertically-aligned-center is-style-marge-normale is-layout-flex wp-container-core-columns-is-layout-9d6595d7 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-vertically-aligned-center is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:15%\"><\/div>\n\n\n\n<div class=\"wp-block-column is-vertically-aligned-center is-layout-flow wp-block-column-is-layout-flow\">\n<div class=\"wp-block-columns are-vertically-aligned-center is-layout-flex wp-container-core-columns-is-layout-9d6595d7 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-vertically-aligned-center is-layout-flow wp-block-column-is-layout-flow\">\n<p><strong>Notre \u00e9quipe collabore avec vous \u00e0 toutes les \u00e9tapes du d\u00e9veloppement du m\u00e9dicament pour choisir la meilleure strat\u00e9gie pour votre \u00e9tude.<\/strong><\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div><\/div>\n\n<div class=\"core core-columns\" ><div class=\"container\">\n<div class=\"wp-block-columns are-vertically-aligned-center is-layout-flex wp-container-core-columns-is-layout-9d6595d7 wp-block-columns-is-layout-flex\" id=\"blockServices\">\n<div class=\"wp-block-column is-vertically-aligned-center is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:33.33%\">\n<h2 class=\"wp-block-heading\">Oncologie<\/h2>\n\n\n\n<p>Le cancer est une pathologie qui englobe un vaste ensemble de maladies susceptibles d\u2019affecter pratiquement tous les organes ou tissus, avec la capacit\u00e9 de se propager \u00e0 d\u2019autres parties du corps. Il constitue la deuxi\u00e8me cause de mortalit\u00e9 dans le monde. Cette urgence sanitaire stimule des recherches intensives et des innovations constantes en oncologie.<\/p>\n\n\n\n<p>Biotrial, une organisation de recherche sous contrat (CRO), poss\u00e8de une solide exp\u00e9rience dans la conduite d&#8217;essais <em>in vitro<\/em> et l&#8217;utilisation de mod\u00e8les <em>in vivo<\/em> pour tester l&#8217;efficacit\u00e9 de nouveaux traitements anticanc\u00e9reux.<\/p>\n\n\n\n<p>Nous collaborons \u00e9troitement avec des entreprises de biotechnologies et pharmaceutiques pour concevoir et mener des \u00e9tudes pr\u00e9cliniques sur mesure en oncologie. Notre objectif est de les aider \u00e0 d\u00e9velopper des traitements anticanc\u00e9reux \u00e0 la fois <strong>s\u00fbrs et efficaces<\/strong>, contribuant ainsi \u00e0 am\u00e9liorer la vie des patients \u00e0 travers le monde.<\/p>\n\n\n\n<p>.<\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-vertically-aligned-center has-gris-clair-2-background-color has-background is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:66.66%\">\n<div class=\"wp-block-columns are-vertically-aligned-top is-layout-flex wp-container-core-columns-is-layout-9d6595d7 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-vertically-aligned-top is-layout-flow wp-block-column-is-layout-flow\">\n<p><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><a><strong><em>In vitro<\/em><\/strong> : Culture primaire, biomarqueurs, validation de cible, pharmacologie mol\u00e9culaire<\/a><\/li>\n\n\n\n<li><strong><em>In vivo<\/em> <\/strong>: Mod\u00e8les de x\u00e9nogreffe, mod\u00e8les syng\u00e9niques, mod\u00e8les de tumeur sp\u00e9cifiques, x\u00e9nogreffe d\u00e9riv\u00e9e de patient<\/li>\n<\/ul>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-vertically-aligned-top is-layout-flow wp-block-column-is-layout-flow\">\n<figure class=\"wp-block-image size-large is-style-rounded\"><picture><source srcset=\"https:\/\/www.biotrial.com\/app\/uploads\/2023\/03\/biotrial_nonclinical_drug_efficacy_oncology-1024x576.webp\" type=\"image\/webp\" \/><img src=\"https:\/\/www.biotrial.com\/app\/uploads\/2023\/03\/biotrial_nonclinical_drug_efficacy_oncology-1024x576.jpg\" width=\"1024\"  height=\"576\" class=\"wp-image-1772\" alt=\"Cancer Cells Vis\" ><\/picture><\/figure>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div><\/div>\n\n<div class=\"core core-columns\" ><div class=\"container\">\n<div class=\"wp-block-columns are-vertically-aligned-center is-layout-flex wp-container-core-columns-is-layout-9d6595d7 wp-block-columns-is-layout-flex\" id=\"blockServices\">\n<div class=\"wp-block-column is-vertically-aligned-center is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:33.33%\">\n<figure class=\"wp-block-image size-full is-style-rounded\"><picture><source srcset=\"https:\/\/www.biotrial.com\/app\/uploads\/2023\/03\/biotrial_nonclinical_drug_efficacy_cns.webp\" type=\"image\/webp\" \/><img src=\"https:\/\/www.biotrial.com\/app\/uploads\/2023\/03\/biotrial_nonclinical_drug_efficacy_cns.jpg\" width=\"512\"  height=\"682\" class=\"wp-image-1766\" alt=\"Biotrial Nonclinical Drug Efficacy Cns\" ><\/picture><\/figure>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-vertically-aligned-center has-gris-clair-2-background-color has-background is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:66.66%\">\n<h2 class=\"wp-block-heading\">Troubles du Syst\u00e8me Nerveux Central (SNC)<\/h2>\n\n\n\n<div class=\"wp-block-columns are-vertically-aligned-top is-layout-flex wp-container-core-columns-is-layout-9d6595d7 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-vertically-aligned-top is-layout-flow wp-block-column-is-layout-flow\">\n<p>Biotrial offre un large \u00e9ventail de mod\u00e8les, des plus <strong>simples aux plus complexes<\/strong>, pour les \u00e9tudes du syst\u00e8me nerveux central (SNC). Nous proposons \u00e9galement la cr\u00e9ation de nouveaux mod\u00e8les adapt\u00e9s aux exigences scientifiques et aux objectifs de chaque projet.<\/p>\n\n\n\n<p>Nous offrons des donn\u00e9es de <strong>validation <\/strong>et une <strong>garantie<\/strong> pour tous nos mod\u00e8les d&#8217;efficacit\u00e9 du SNC. En tant que CRO, nous vous accompagnons dans la transition des \u00e9tudes pr\u00e9cliniques aux essais cliniques de phase I \u00e0 IV.<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Donn\u00e9es de validation et garantie scientifique<\/li>\n\n\n\n<li>Services translationnels<\/li>\n\n\n\n<li>Techniques compl\u00e9mentaires<\/li>\n<\/ul>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-vertically-aligned-top is-layout-flow wp-block-column-is-layout-flow\">\n<p>A Biotrial, l\u2019\u00e9valuation de l\u2019efficacit\u00e9 de mol\u00e9cules destin\u00e9es \u00e0 des pathologies du SNC comprend des mod\u00e8les valid\u00e9s pour les domaines suivants :<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Psychiatrie : anxi\u00e9t\u00e9, d\u00e9pression, trouble de panique<\/li>\n\n\n\n<li>Schizophr\u00e9nie : sympt\u00f4mes positifs, sympt\u00f4mes n\u00e9gatifs et dysfonctionnement cognitif<\/li>\n\n\n\n<li>Troubles neurologiques : maladie d&#8217;Alzheimer, maladie de Parkinson<\/li>\n\n\n\n<li>Tests de M\u00e9moire<\/li>\n\n\n\n<li>Electroenc\u00e9phalogramme (EEG)<\/li>\n<\/ul>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div><\/div>\n\n<section class=\"core-inline core-heading\" ><div class=\"container\">\n<h2 class=\"wp-block-heading\">Fonction cardiovasculaire &amp; h\u00e9mostase<\/h2>\n<\/div><\/section>\n\n<div class=\"core core-columns\" ><div class=\"container\">\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-9d6595d7 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<p>Les maladies cardiovasculaires, qui touchent le c\u0153ur et les vaisseaux sanguins, restent la premi\u00e8re cause de mortalit\u00e9 mondiale. La recherche continue dans ce domaine ouvre la voie \u00e0 des solutions innovantes.<\/p>\n\n\n\n<p>Depuis de nombreuses ann\u00e9es, nous r\u00e9alisons des \u00e9tudes d\u2019\u00e9valuation de la fonction cardiaque et h\u00e9modynamique sur des rongeurs et gros animaux. Nous proposons des mod\u00e8les <strong>pathophysiologiques<\/strong> <strong>d\u2019arythmies cardiaques<\/strong>, d\u2019insuffisance cardiaque et de <strong>thrombose<\/strong>, et disposons d\u2019une large exp\u00e9rience dans la r\u00e9alisation d\u2019\u00e9tudes de <strong>t\u00e9l\u00e9m\u00e9trie<\/strong> <strong>cardiovasculaire<\/strong> sur toutes les esp\u00e8ces.<\/p>\n\n\n\n<p>Nous proposons une gamme compl\u00e8te de services de tests d&#8217;efficacit\u00e9 pr\u00e9cliniques en cardiologie, incluant :<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Des \u00e9tudes de pharmacologie de <strong>s\u00e9curit\u00e9 cardiaque<\/strong> pour \u00e9valuer la cardiotoxicit\u00e9 potentielle de nouveaux m\u00e9dicaments.<\/li>\n\n\n\n<li>Des mod\u00e8les de <strong>pathophysiologie cardiovasculaire <\/strong>pour \u00e9tudier les effets des m\u00e9dicaments sur des maladies cardiovasculaires sp\u00e9cifiques, telles que les arythmies, l&#8217;insuffisance cardiaque et la thrombose.<\/li>\n\n\n\n<li>Des \u00e9tudes de t\u00e9l\u00e9m\u00e9trie pour surveiller les effets cardiovasculaires des m\u00e9dicaments.<\/li>\n<\/ul>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-9d6595d7 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\"><\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\"><\/div>\n<\/div>\n\n\n\n<figure class=\"wp-block-gallery has-nested-images columns-default is-cropped wp-block-gallery-1 is-layout-flex wp-block-gallery-is-layout-flex\">\n<figure class=\"wp-block-image size-large is-resized is-style-rounded\"><picture><source srcset=\"https:\/\/www.biotrial.com\/app\/uploads\/2024\/09\/biotrial_nonclinical_drug_efficacy_hemostasis-edited-1024x778.webp\" type=\"image\/webp\" \/><img src=\"https:\/\/www.biotrial.com\/app\/uploads\/2024\/09\/biotrial_nonclinical_drug_efficacy_hemostasis-edited-1024x778.jpg\" width=\"1024\"  height=\"778\" class=\"wp-image-10461\" alt=\"Blood Cells Visual\" ><\/picture><\/figure>\n\n\n\n<figure class=\"wp-block-image size-large is-resized is-style-rounded\"><picture><source srcset=\"https:\/\/www.biotrial.com\/app\/uploads\/2023\/03\/biotrial_nonclinical_follow_up_cardiovascular-1024x1024.webp\" type=\"image\/webp\" \/><img src=\"https:\/\/www.biotrial.com\/app\/uploads\/2023\/03\/biotrial_nonclinical_follow_up_cardiovascular-1024x1024.jpg\" width=\"1024\"  height=\"1024\" class=\"wp-image-7955\" alt=\"\" loading=\"lazy\"><\/picture><\/figure>\n<\/figure>\n<\/div>\n<\/div>\n<\/div><\/div>\n\n<section class=\"core-inline core-heading\" ><div class=\"container\">\n<h2 class=\"wp-block-heading\">Fonction respiratoire<\/h2>\n<\/div><\/section>\n\n<section class=\"core core-media-text\" ><div class=\"container\">\n<div class=\"wp-block-media-text alignwide is-stacked-on-mobile is-style-img-is-rounded\"><figure class=\"wp-block-media-text__media\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"576\" src=\"https:\/\/www.biotrial.com\/app\/uploads\/2023\/03\/biotrial_nonclinical_drug_efficacy_respiratory-1024x576.jpg\" alt=\"Biotrial Nonclinical Drug Efficacy Respiratory\" class=\"wp-image-1775 size-full\" srcset=\"https:\/\/www.biotrial.com\/app\/uploads\/2023\/03\/biotrial_nonclinical_drug_efficacy_respiratory-1024x576.jpg 1024w, https:\/\/www.biotrial.com\/app\/uploads\/2023\/03\/biotrial_nonclinical_drug_efficacy_respiratory-300x169.jpg 300w, https:\/\/www.biotrial.com\/app\/uploads\/2023\/03\/biotrial_nonclinical_drug_efficacy_respiratory-768x432.jpg 768w, https:\/\/www.biotrial.com\/app\/uploads\/2023\/03\/biotrial_nonclinical_drug_efficacy_respiratory-1536x864.jpg 1536w, https:\/\/www.biotrial.com\/app\/uploads\/2023\/03\/biotrial_nonclinical_drug_efficacy_respiratory.jpg 2000w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/figure><div class=\"wp-block-media-text__content\">\n<p>Les maladies respiratoires impactent les voies a\u00e9riennes et autres structures des poumons. A Biotrial, notre unit\u00e9 pr\u00e9clinique s\u2019applique \u00e0 \u00e9valuer la s\u00e9curit\u00e9 et l\u2019efficacit\u00e9 de nouvelles th\u00e9rapies contre les maladies respiratoires. Nous disposons \u00e9galement de la pl\u00e9thysmographie de corps entier et de mod\u00e8les valid\u00e9s chez le rongeur pour l\u2019\u00e9valuation des m\u00e9dicaments destin\u00e9s \u00e0 traiter les pathologies respiratoires telles que&nbsp;:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u0152d\u00e8me pulmonaire<\/li>\n\n\n\n<li>Inflammation des voies respiratoires<\/li>\n\n\n\n<li>BPCO (Bronchopneumopathie Chronique Obstructive)<\/li>\n<\/ul>\n\n\n\n<p>Nous disposons \u00e9galement de la technologie de pl\u00e9thysmographie de corps entier pour l\u2019\u00e9valuation de la fonction respiratoire chez les rongeurs.<\/p>\n<\/div><\/div>\n<\/div><\/section>\n\n<section class=\"core-inline core-heading\" ><div class=\"container\">\n<h2 class=\"wp-block-heading\">Fonction r\u00e9nale et gastro-intestinale<\/h2>\n<\/div><\/section>\n\n<section class=\"core core-group\" ><div class=\"container\">\n<div class=\"wp-block-group\"><div class=\"wp-block-group__inner-container is-layout-constrained wp-block-group-is-layout-constrained\">\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-9d6595d7 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<p>Les reins filtrent les d\u00e9chets et les fluides en exc\u00e8s dans le sang, qui sont ensuite excr\u00e9t\u00e9s dans l\u2019urine. La d\u00e9faillance r\u00e9nale d\u00e9crit la perte progressive de la fonction r\u00e9nale, qui peut conduire \u00e0 des niveaux \u00e9lev\u00e9s de fluides, d\u2019\u00e9lectrolytes et de d\u00e9chets dans l\u2019organisme.<\/p>\n\n\n\n<p>Les maladies gastro-intestinales (GI) affectent le tractus gastro-intestinal, de la bouche \u00e0 l\u2019anus. De nombreux facteurs peuvent perturber le tractus GI, conduisant \u00e0 diverses pathologies structurelles et\/ou fonctionnelles. Notre recherche nous aide \u00e0 comprendre les causes et les m\u00e9canismes des maladies affectant ces organes, et aide nos sponsors \u00e0 d\u00e9velopper de nouveaux traitements pour les humains.<\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-9d6595d7 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<figure class=\"wp-block-image size-large is-style-rounded\"><picture><source srcset=\"https:\/\/www.biotrial.com\/app\/uploads\/2023\/03\/biotrial_nonclinical_follow_up_respiratory-1024x571.webp\" type=\"image\/webp\" \/><img src=\"https:\/\/www.biotrial.com\/app\/uploads\/2023\/03\/biotrial_nonclinical_follow_up_respiratory-1024x571.jpg\" width=\"1024\"  height=\"571\" class=\"wp-image-1729\" alt=\"Biotrial Nonclinical Follow Up Respiratory\" loading=\"lazy\"><\/picture><\/figure>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<figure class=\"wp-block-image size-large is-style-rounded\"><picture><source srcset=\"https:\/\/www.biotrial.com\/app\/uploads\/2023\/03\/biotrial_nonclinical_drug_efficacy_gastro_intestinal-1024x576.webp\" type=\"image\/webp\" \/><img src=\"https:\/\/www.biotrial.com\/app\/uploads\/2023\/03\/biotrial_nonclinical_drug_efficacy_gastro_intestinal-1024x576.jpg\" width=\"1024\"  height=\"576\" class=\"wp-image-1768\" alt=\"Human Digestive System Anatomy\" loading=\"lazy\"><\/picture><\/figure>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-9d6595d7 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<p><strong><strong>Exemple de mod\u00e8les disponibles de maladies GI (Gastro-Intestinales)<\/strong><\/strong><br><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Maladie inflammatoire chronique de l\u2019intestin (MICI)<\/li>\n\n\n\n<li>Fistule p\u00e9rianale<\/li>\n<\/ul>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<p><strong><strong>Evaluation de la fonction gastro-intestinale<\/strong><\/strong><br><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Motilit\u00e9 GI<\/li>\n\n\n\n<li>Vidange gastrique<\/li>\n<\/ul>\n<\/div>\n<\/div>\n<\/div><\/div>\n<\/div><\/section>\n\n<section class=\"core core-media-text\" ><div class=\"container\">\n<div class=\"wp-block-media-text alignwide has-media-on-the-right is-stacked-on-mobile is-style-img-is-rounded\" style=\"grid-template-columns:auto 38%\"><div class=\"wp-block-media-text__content\">\n<h2 class=\"wp-block-heading\">Notre \u00e9quipe pr\u00e9clinique<\/h2>\n\n\n\n<p>L&#8217;\u00e9quipe pr\u00e9clinique de Biotrial poss\u00e8de une vaste exp\u00e9rience et une expertise approfondie dans l&#8217;\u00e9valuation de l&#8217;efficacit\u00e9 des nouveaux m\u00e9dicaments. Compos\u00e9e de scientifiques hautement qualifi\u00e9s, ma\u00eetrisant parfaitement le processus des tests d&#8217;efficacit\u00e9 pr\u00e9cliniques, notre \u00e9quipe s&#8217;engage \u00e0 offrir des services d&#8217;\u00e9valuation complets aux sponsors.<\/p>\n<\/div><figure class=\"wp-block-media-text__media\"><img decoding=\"async\" src=\"https:\/\/www.biotrial.com\/app\/uploads\/2023\/09\/2211023-biotrial-pdv-reportage-01-182-1024x768.jpg\" alt=\"Biotrial-preclinical-team\" class=\"wp-image-6323 size-full\"\/><\/figure><\/div>\n<\/div><\/section>\n\n\n<section class=\"acf downloads\" id=\"Resources\">\n    <div class=\"container\">\n                    <h2>RESSOURCES<\/h2>\n                            <div class=\"contain-downloads\">\n                                                            <div class=\"download ask-for-personal-informations\" data-file=\"8014\" data-portal=\"144590169\" data-form=\"d8d49dde-6ce0-4b8d-898b-f208826bd9b1\" style=\"background-color:#134052\">\n                            <span>Blocage aigu des r\u00e9cepteurs NMDA chez les rats reproduisant les caract\u00e9ristiques comportementales et \u00e9lectrophysiologiques de la schizophr\u00e9nie<\/span>\n                        <\/div>\n                                                                                <div class=\"download ask-for-personal-informations\" data-file=\"7963\" data-portal=\"144590169\" data-form=\"1f2e2284-77a1-41e2-8132-e826830684c1\" style=\"background-color:#134052\">\n                            <span>Profilage \u00e9lectrophysiologique de l&#8217;escitalopram chez les rongeurs et les sujets humains en bonne sant\u00e9<\/span>\n                        <\/div>\n                                                                                <div class=\"download ask-for-personal-informations\" data-file=\"8010\" data-portal=\"144590169\" data-form=\"8ef7d45e-80c4-47bc-8691-988f63357061\" style=\"background-color:#134052\">\n                            <span>D\u00e9tection et modulation pharmacologique des fuseaux de sommeil chez le rat<\/span>\n                        <\/div>\n                                                <\/div>\n            <\/div>\n<\/section>\n<dialog class=\"downloadFile\" id=\"dialogDownloadFile_2\">\n    <div class=\"content\">\n        <div class=\"contain-text\">\n                                                <div class=\"text\" data-file=\"8014\" data-portal=\"144590169\" data-form=\"d8d49dde-6ce0-4b8d-898b-f208826bd9b1\">\n                                                                            <strong class=\"title\">Acutely blocking NMDA receptors in rats reproduces behavioral and electrophysiological features of schizophrenia: a robust and translational tool to assess antipsychotics and investigational drugs indicated for the treatment of schizophrenia<\/strong>\n                                                                            <div class=\"txt\"><p>ABSTRACT: The therapeutic management of Schizophrenia (SZ) has not<br \/>\nsignificantly improved since the first commercialization of atypical<br \/>\nantipsychotics. Mostly targeting positive symptoms of SZ, these drugs<br \/>\ndo not treat other aspects of the disease such as social dysfunction<br \/>\nand do not sufficiently modify SZ underlying neurobiology. The lack of<br \/>\nnew innovative therapies for SZ has raised the question of the<br \/>\nrobustness and translatability of preclinical methods used during<br \/>\ndrug development. Here, we highlight a robust and translational<br \/>\nmodel aiming at evaluating drugs indicated for the treatment of SZ.<br \/>\nSZ being mainly mediated by N-methyl-D-aspartate receptor (NMDAr)<br \/>\nhypofunction, this model relies on blocking NMDAr with MK-801 in<br \/>\nthe rat. Importantly, this model includes both behavioral (locomotor<br \/>\nactivity (LMA) evaluation to assess psychotic-like behavior and social<br \/>\ninteraction analysis) and EEG readouts (gamma-band auditory steadystate<br \/>\nresponse (ASSR) and quantitative EEG (qEEG)) to align with<br \/>\nmethods used in patients. This preclinical method thereby allows<br \/>\nfocusing on both clinical manifestations (positive symptoms and social<br \/>\ndysfunction) and NMDAr-hypofunction-mediated excitationinhibition<br \/>\n(E\/I) imbalance, a key pillar of SZ for which the gammaband<br \/>\nASSR is seen as a translational EEG biomarker. To further evaluate<br \/>\nthis approach, the atypical antipsychotics clozapine and aripiprazole<br \/>\nwere evaluated on parameters influenced by MK-801 administration.<\/p>\n<\/div>\n                            <span class=\"link disableReadExtractLink\">Fermer le r\u00e9sum\u00e9 et t\u00e9l\u00e9charger<\/span>\n                                            <\/div>\n                                                                <div class=\"text\" data-file=\"7963\" data-portal=\"144590169\" data-form=\"1f2e2284-77a1-41e2-8132-e826830684c1\">\n                                                                            <strong class=\"title\">Profilage \u00e9lectrophysiologique de l&#8217;escitalopram chez les rongeurs et les sujets humains en bonne sant\u00e9<\/strong>\n                                                                            <div class=\"txt\"><p>Major depressive disorder (MDD) is a severe and common psychiatric disorder and although it primarily involves mood disturbances, patients usually present alterations in cognitive function.<br \/>\nCognitive performance is assessed through the use of behavioural tasks but this does not allow for the establishment of a pharmacodynamic marker of underlying brain activity. Identifying<br \/>\nneurophysiological markers with a correlation to cognitive performance could increase the clinical utility of pharmacological compounds. This study was aimed at exploring neurophysiological<br \/>\npharmacodynamic markers of cognitive performance for escitalopram, a selective serotonin reuptake inhibitor (SSRI). SSRIs have been the leading class of drugs for the treatment of depression<br \/>\nand anxiety for several decades and have been associated with a number of sensitive peripheral and central biomarkers. Quantitative electroencephalography (qEEG) and auditory steady-state<br \/>\nresponses (ASSRs; electrophysiological responses entrained to the frequency and phase of a rapid auditory stimuli) were investigated in human healthy subjects and Wistar rats following<br \/>\ntreatment with escitalopram.<\/p>\n<\/div>\n                            <span class=\"link disableReadExtractLink\">Fermer le r\u00e9sum\u00e9 et t\u00e9l\u00e9charger<\/span>\n                                            <\/div>\n                                                                <div class=\"text\" data-file=\"8010\" data-portal=\"144590169\" data-form=\"8ef7d45e-80c4-47bc-8691-988f63357061\">\n                                                                            <strong class=\"title\">D\u00e9tection et modulation pharmacologique des fuseaux de sommeil chez le rat<\/strong>\n                                                                            <div class=\"txt\"><p>Successful CNS drug development relies on using quantitative &amp; predictive preclinical methods to better assess efficacy &amp; safety. Sleep spindles (SPI) are EEG hallmark of mammals\u2019 NREM sleep involved in cognition and memory that depend on CaV3.3 Ca2+ channels of the thalamic reticular nucleus. SPI are reduced in a number of pathologies including Schizophrenia and Alzheimer\u2019s disease. They might therefore provide valuable &amp; translational information regarding target engagement, efficacy and safety.<\/p>\n<\/div>\n                            <span class=\"link disableReadExtractLink\">Fermer le r\u00e9sum\u00e9 et t\u00e9l\u00e9charger<\/span>\n                                            <\/div>\n                                        <span class=\"link readExtractLink\">Lire le r\u00e9sum\u00e9<\/span>\n        <\/div>\n        <div class=\"contain-form\">\n            <h2>T\u00e9l\u00e9chargement de nos posters scientifiques<\/h2>\n                            <p>Veuillez remplir les informations ci-dessous pour acc\u00e9der au t\u00e9l\u00e9chargement.<\/p>\n                        <div class=\"msg msgDownloadFile\"><\/div>\n            <div class=\"contain-form containFormDownloadFile\">\n\n                <div id=\"block_3278e36d8b124277a374a2816a2560d5_form\" class=\"hubspot-form\"><\/div>\n\n                <span class=\"description\">Toutes les informations marqu\u00e9es d&#8217;un &#8220;*&#8221; sont obligatoires.<\/span>\n                <div class=\"input\">\n                    <label for=\"lastnameDownloadFile\">Nom*<\/label>\n                    <div class=\"form-input person\">\n                        <input type=\"text\" class=\"lastnameDownloadFile\">\n                    <\/div>\n                <\/div>\n                <div class=\"input\">\n                    <label for=\"firstnameDownloadFile\">Pr\u00e9nom*<\/label>\n                    <div class=\"form-input person\">\n                        <input type=\"text\" class=\"firstnameDownloadFile\">\n                    <\/div>\n                <\/div>\n                <div class=\"input\">\n                    <label for=\"emailDownloadFile\">Email*<\/label>\n                    <div class=\"form-input mail\">\n                        <input type=\"email\" class=\"emailDownloadFile\">\n                    <\/div>\n                <\/div>\n                <div class=\"input\">\n                    <label for=\"companyDownloadFile\">Entreprise*<\/label>\n                    <div class=\"form-input travel\">\n                        <input type=\"text\" class=\"companyDownloadFile\">\n                    <\/div>\n                <\/div>\n                <div class=\"form-input large agree-terms\">\n                    <input type=\"checkbox\" class=\"agreeDownloadFile\" id=\"agreeDownloadFile_2\">\n                    <label for=\"agreeDownloadFile_2\" class=\"label-checkbox\">J&#8217;accepte que Biotrial utilise mes informations conform\u00e9ment \u00e0 leur <a href=\"https:\/\/www.biotrial.com\/fr-ca\/\/legal-notices\/\" target=\"_blank\">Politique de confidentialit\u00e9 et mentions l\u00e9gales<\/a>.<\/label>\n                <\/div>\n                <input type=\"hidden\" class=\"idDownloadFile\">\n                <div class=\"btn full white btnConfirmDownloadFile\">\n                    <span>T\u00e9l\u00e9charger le document<\/span>\n                <\/div>\n\n            <\/div>\n                \n        <\/div>\n    <\/div>\n    <span class=\"closeModal\">Fermer<\/span>\n<\/dialog>\n<script>\n    var downloadNonce = 'd28455b7e7';\n    var files = document.getElementsByClassName('ask-for-personal-informations');\n    for (var i = 0; i < files.length; i++) {\n        initFormDownloadFile(files.item(i));\n    }\n    sendFormDownloadFile();\n    function initFormDownloadFile(file){\n        file.addEventListener('click', function(){\n            var idFile          = this.dataset.file;\n            var idPortal        = this.dataset.portal;\n            var idForm          = this.dataset.form;\n\n            document.body.classList.add('blur');\n            var dialogElement = file.closest('.downloads').nextElementSibling\n            if(dialogElement.querySelector('.agreeDownloadFile')?.checked){\n                dialogElement.querySelector('.agreeDownloadFile').nextElementSibling.click();\n            }\n            dialogElement.querySelector('.msgDownloadFile').innerHTML    = '';\n            if(dialogElement.querySelector('.idDownloadFile')){\n                dialogElement.querySelector('.idDownloadFile').value         = idFile;\n            }\n            dialogElement.classList.remove('has-success');\n            var has_text = false\n            dialogElement.querySelectorAll('.text').forEach((text) => {\n                if(text.dataset.file == idFile){\n                    has_text = true\n                    dialogElement.classList.add('has-text')\n                    text.classList.add('visible')\n                } else{\n                    text.classList.remove('visible')\n                }\n            })\n            if(!has_text){\n                dialogElement.classList.remove('has-text')\n            }\n            dialogElement.querySelector('.readExtractLink').addEventListener('click', (e) => {\n                e.target.closest('dialog').classList.add('read-extract')\n            })\n            dialogElement.querySelectorAll('.disableReadExtractLink').forEach((link) => {\n                link.addEventListener('click', (e) => {\n                    e.target.closest('dialog').classList.remove('read-extract')\n                    e.target.closest('dialog').querySelector('.contain-text').scrollTop = 0\n                })\n            })\n            if(idPortal && idForm){\n                dialogElement.querySelector('.containFormDownloadFile').classList.add('has-hubspot-form')\n                hbspt.forms.create({\n                    portalId: idPortal,\n                    formId: idForm,\n                    target: \"#block_3278e36d8b124277a374a2816a2560d5_form\",\n                    css: '',\n                    onFormSubmitted: function(element, event) {\n                        console.log(event)\n                    }\n                });\n            } else{\n                dialogElement.querySelector('.containFormDownloadFile').classList.remove('has-hubspot-form')\n            }\n            dialogElement.showModal();\n        })\n    }\n    function sendFormDownloadFile(){\n        var dialogElement     = document.querySelector('#dialogDownloadFile_2') \n        function setDownloadMessage(type, message){\n            var errorMsg = dialogElement.querySelector('.msgDownloadFile');\n            if(!errorMsg) return;\n            var p = document.createElement('p');\n            p.className = (type === 'success') ? 'success' : 'error';\n            p.textContent = message || '';\n            errorMsg.innerHTML = '';\n            errorMsg.appendChild(p);\n        }\n        dialogElement.querySelector('.btnConfirmDownloadFile')?.addEventListener('click', function(){\n            var idFileInput         = dialogElement.querySelector('.idDownloadFile').value;\n            var lastnameFileInput   = dialogElement.querySelector('.lastnameDownloadFile').value;\n            var firstnameFileInput  = dialogElement.querySelector('.firstnameDownloadFile').value;\n            var emailFileInput      = dialogElement.querySelector('.emailDownloadFile').value;\n            var companyFileInput    = dialogElement.querySelector('.companyDownloadFile').value;\n            var agreeDownloadFile   = dialogElement.querySelector('.agreeDownloadFile').checked;\n            var req                 = new XMLHttpRequest();\n            var getUrl              = window.location;\n            var formData            = new FormData();\n            formData.append('idFileInput', idFileInput);   \n            formData.append('lastnameFileInput', lastnameFileInput); \n            formData.append('firstnameFileInput', firstnameFileInput); \n            formData.append('emailFileInput', emailFileInput); \n            formData.append('companyFileInput', companyFileInput);\n            formData.append('agreeDownloadFile', agreeDownloadFile);\n            formData.append('action', 'form_downloadfile');\n            formData.append('security', downloadNonce);\n            req.open('POST', \"https:\/\/www.biotrial.com\/fr-ca\/\/wp\/wp-admin\/admin-ajax.php\", true);\n            req.setRequestHeader('X-Requested-With', 'XMLHttpRequest');\n            req.onload = function() {\n                if (req.status === 200) {\n                    var response;\n                    try{\n                        response = JSON.parse(req.response);\n                    } catch (e){\n                        setDownloadMessage('error', 'An\\u0020unexpected\\u0020error\\u0020occurred.\\u0020Please\\u0020try\\u0020again.');\n                        return;\n                    }\n                    if(response.type == \"error\"){\n                        setDownloadMessage('error', response.content);\n                    } else if(response.type == \"success\"){\n                        setDownloadMessage('success', response.content);\n                        dialogElement.classList.add('has-success');\n                        dialogElement.querySelector('.lastnameDownloadFile').value   = \"\";\n                        dialogElement.querySelector('.firstnameDownloadFile').value  = \"\";\n                        dialogElement.querySelector('.emailDownloadFile').value      = \"\";\n                        dialogElement.querySelector('.companyDownloadFile').value    = \"\";\n                        var fileUrl = new URL(response.file, window.location.origin);\n                        if (fileUrl.origin !== window.location.origin) {\n                            setDownloadMessage('error', 'Une\\u0020erreur\\u0020est\\u0020survenue\\u0020lors\\u0020de\\u0020la\\u0020r\\u00E9cup\\u00E9ration\\u0020du\\u0020fichier.\\u0020Veuillez\\u0020nous\\u0020contacter.');\n                            return;\n                        }\n                        fetch(fileUrl.toString()).then(res => res.blob()).then(file => {\n                            let tempUrl     = URL.createObjectURL(file);\n                            var aTag      = document.createElement(\"a\");\n                            aTag.href       = tempUrl;\n                            aTag.download   = fileUrl.pathname.replace(\/^.*[\\\\\\\/]\/, '');\n                            document.body.appendChild(aTag);\n                            aTag.click();\n                            URL.revokeObjectURL(tempUrl);\n                            aTag.remove();\n                        }).catch(function(){\n                            setDownloadMessage('error', 'Une\\u0020erreur\\u0020est\\u0020survenue\\u0020lors\\u0020de\\u0020la\\u0020r\\u00E9cup\\u00E9ration\\u0020du\\u0020fichier.\\u0020Veuillez\\u0020nous\\u0020contacter.');\n                        });\n                    }\n                } else{\n                    setDownloadMessage('error', 'An\\u0020unexpected\\u0020error\\u0020occurred.\\u0020Please\\u0020try\\u0020again.');\n                }\n            };\n            req.send(formData);\n        });\n    }\n<\/script>\n\n\n<section class=\"acf links\" id=\"blockInformation\">\n    <div class=\"container\">\n                    <h2>D\u00e9couvrir \u00e9galement<\/h2>\n                <div class=\"links\">\n                            <a class=\"link-slider\" href=\"https:\/\/www.biotrial.com\/fr-ca\/solutions-services\/preclinique\/securite\/\">\n                                            <span class=\"label\">S\u00e9curit\u00e9 des m\u00e9dicaments<\/span>\n                                    <\/a>\n                            <a class=\"link-slider\" href=\"https:\/\/www.biotrial.com\/fr-ca\/solutions-services\/preclinique\/etudes-de-pk\/\">\n                                            <span class=\"label\">\u00c9tudes de PK<\/span>\n                                    <\/a>\n                            <a class=\"link-slider\" href=\"https:\/\/www.biotrial.com\/fr-ca\/solutions-services\/preclinique\/developpement-de-modele\/\">\n                                            <span class=\"label\">D\u00e9veloppement de mod\u00e8le<\/span>\n                                    <\/a>\n                    <\/div>\n    <\/div>\n<\/section>","protected":false},"excerpt":{"rendered":"<p>Notre \u00e9quipe collabore avec vous \u00e0 toutes les \u00e9tapes du d\u00e9veloppement du m\u00e9dicament pour choisir la meilleure strat\u00e9gie pour votre \u00e9tude. Oncologie Le cancer est une pathologie qui englobe un vaste ensemble de maladies susceptibles d\u2019affecter pratiquement tous les organes ou tissus, avec la capacit\u00e9 de se propager \u00e0 d\u2019autres parties du corps. Il constitue [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":7898,"menu_order":1,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"footnotes":""},"class_list":["post-7951","page","type-page","status-publish","hentry"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>CRO | Services pr\u00e9cliniques | Efficacit\u00e9 des m\u00e9dicaments | Biotrial<\/title>\n<meta name=\"description\" content=\"D\u00e9couvrez comment Biotrial r\u00e9pond \u00e0 votre probl\u00e9matique d&#039;\u00e9valuation de l&#039;efficacit\u00e9 de votre m\u00e9dicament en pr\u00e9clinique.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.biotrial.com\/fr-ca\/solutions-services\/preclinique\/efficacite\/\" \/>\n<meta property=\"og:locale\" content=\"fr_CA\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"CRO | Services pr\u00e9cliniques | Efficacit\u00e9 des m\u00e9dicaments | Biotrial\" \/>\n<meta property=\"og:description\" content=\"D\u00e9couvrez comment Biotrial r\u00e9pond \u00e0 votre probl\u00e9matique d&#039;\u00e9valuation de l&#039;efficacit\u00e9 de votre m\u00e9dicament en pr\u00e9clinique.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.biotrial.com\/fr-ca\/solutions-services\/preclinique\/efficacite\/\" \/>\n<meta property=\"og:site_name\" content=\"Biotrial\" \/>\n<meta property=\"article:modified_time\" content=\"2024-11-21T13:41:46+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.biotrial.com\/app\/uploads\/2023\/03\/biotrial_nonclinical_drug_efficacy_oncology-1024x576.jpg\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"5 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/www.biotrial.com\\\/fr-ca\\\/solutions-services\\\/preclinique\\\/efficacite\\\/\",\"url\":\"https:\\\/\\\/www.biotrial.com\\\/fr-ca\\\/solutions-services\\\/preclinique\\\/efficacite\\\/\",\"name\":\"CRO | Services pr\u00e9cliniques | Efficacit\u00e9 des m\u00e9dicaments | Biotrial\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.biotrial.com\\\/fr-ca\\\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\\\/\\\/www.biotrial.com\\\/fr-ca\\\/solutions-services\\\/preclinique\\\/efficacite\\\/#primaryimage\"},\"image\":{\"@id\":\"https:\\\/\\\/www.biotrial.com\\\/fr-ca\\\/solutions-services\\\/preclinique\\\/efficacite\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/www.biotrial.com\\\/app\\\/uploads\\\/2023\\\/03\\\/biotrial_nonclinical_drug_efficacy_oncology-1024x576.jpg\",\"datePublished\":\"2023-02-07T13:39:15+00:00\",\"dateModified\":\"2024-11-21T13:41:46+00:00\",\"description\":\"D\u00e9couvrez comment Biotrial r\u00e9pond \u00e0 votre probl\u00e9matique d'\u00e9valuation de l'efficacit\u00e9 de votre m\u00e9dicament en pr\u00e9clinique.\",\"breadcrumb\":{\"@id\":\"https:\\\/\\\/www.biotrial.com\\\/fr-ca\\\/solutions-services\\\/preclinique\\\/efficacite\\\/#breadcrumb\"},\"inLanguage\":\"fr-CA\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/www.biotrial.com\\\/fr-ca\\\/solutions-services\\\/preclinique\\\/efficacite\\\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"fr-CA\",\"@id\":\"https:\\\/\\\/www.biotrial.com\\\/fr-ca\\\/solutions-services\\\/preclinique\\\/efficacite\\\/#primaryimage\",\"url\":\"https:\\\/\\\/www.biotrial.com\\\/app\\\/uploads\\\/2023\\\/03\\\/biotrial_nonclinical_drug_efficacy_oncology-1024x576.jpg\",\"contentUrl\":\"https:\\\/\\\/www.biotrial.com\\\/app\\\/uploads\\\/2023\\\/03\\\/biotrial_nonclinical_drug_efficacy_oncology-1024x576.jpg\"},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/www.biotrial.com\\\/fr-ca\\\/solutions-services\\\/preclinique\\\/efficacite\\\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\\\/\\\/www.biotrial.com\\\/fr-ca\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Solutions &#038; Services\",\"item\":\"https:\\\/\\\/www.biotrial.com\\\/fr-ca\\\/solutions-services\\\/\"},{\"@type\":\"ListItem\",\"position\":3,\"name\":\"Pr\u00e9clinique\",\"item\":\"https:\\\/\\\/www.biotrial.com\\\/fr-ca\\\/solutions-services\\\/preclinique\\\/\"},{\"@type\":\"ListItem\",\"position\":4,\"name\":\"Efficacit\u00e9\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/www.biotrial.com\\\/fr-ca\\\/#website\",\"url\":\"https:\\\/\\\/www.biotrial.com\\\/fr-ca\\\/\",\"name\":\"Biotrial\",\"description\":\"Just another WordPress site\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/www.biotrial.com\\\/fr-ca\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"fr-CA\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"CRO | Services pr\u00e9cliniques | Efficacit\u00e9 des m\u00e9dicaments | Biotrial","description":"D\u00e9couvrez comment Biotrial r\u00e9pond \u00e0 votre probl\u00e9matique d'\u00e9valuation de l'efficacit\u00e9 de votre m\u00e9dicament en pr\u00e9clinique.","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.biotrial.com\/fr-ca\/solutions-services\/preclinique\/efficacite\/","og_locale":"fr_CA","og_type":"article","og_title":"CRO | Services pr\u00e9cliniques | Efficacit\u00e9 des m\u00e9dicaments | Biotrial","og_description":"D\u00e9couvrez comment Biotrial r\u00e9pond \u00e0 votre probl\u00e9matique d'\u00e9valuation de l'efficacit\u00e9 de votre m\u00e9dicament en pr\u00e9clinique.","og_url":"https:\/\/www.biotrial.com\/fr-ca\/solutions-services\/preclinique\/efficacite\/","og_site_name":"Biotrial","article_modified_time":"2024-11-21T13:41:46+00:00","og_image":[{"url":"https:\/\/www.biotrial.com\/app\/uploads\/2023\/03\/biotrial_nonclinical_drug_efficacy_oncology-1024x576.jpg","type":"","width":"","height":""}],"twitter_card":"summary_large_image","twitter_misc":{"Est. reading time":"5 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/www.biotrial.com\/fr-ca\/solutions-services\/preclinique\/efficacite\/","url":"https:\/\/www.biotrial.com\/fr-ca\/solutions-services\/preclinique\/efficacite\/","name":"CRO | Services pr\u00e9cliniques | Efficacit\u00e9 des m\u00e9dicaments | Biotrial","isPartOf":{"@id":"https:\/\/www.biotrial.com\/fr-ca\/#website"},"primaryImageOfPage":{"@id":"https:\/\/www.biotrial.com\/fr-ca\/solutions-services\/preclinique\/efficacite\/#primaryimage"},"image":{"@id":"https:\/\/www.biotrial.com\/fr-ca\/solutions-services\/preclinique\/efficacite\/#primaryimage"},"thumbnailUrl":"https:\/\/www.biotrial.com\/app\/uploads\/2023\/03\/biotrial_nonclinical_drug_efficacy_oncology-1024x576.jpg","datePublished":"2023-02-07T13:39:15+00:00","dateModified":"2024-11-21T13:41:46+00:00","description":"D\u00e9couvrez comment Biotrial r\u00e9pond \u00e0 votre probl\u00e9matique d'\u00e9valuation de l'efficacit\u00e9 de votre m\u00e9dicament en pr\u00e9clinique.","breadcrumb":{"@id":"https:\/\/www.biotrial.com\/fr-ca\/solutions-services\/preclinique\/efficacite\/#breadcrumb"},"inLanguage":"fr-CA","potentialAction":[{"@type":"ReadAction","target":["https:\/\/www.biotrial.com\/fr-ca\/solutions-services\/preclinique\/efficacite\/"]}]},{"@type":"ImageObject","inLanguage":"fr-CA","@id":"https:\/\/www.biotrial.com\/fr-ca\/solutions-services\/preclinique\/efficacite\/#primaryimage","url":"https:\/\/www.biotrial.com\/app\/uploads\/2023\/03\/biotrial_nonclinical_drug_efficacy_oncology-1024x576.jpg","contentUrl":"https:\/\/www.biotrial.com\/app\/uploads\/2023\/03\/biotrial_nonclinical_drug_efficacy_oncology-1024x576.jpg"},{"@type":"BreadcrumbList","@id":"https:\/\/www.biotrial.com\/fr-ca\/solutions-services\/preclinique\/efficacite\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/www.biotrial.com\/fr-ca\/"},{"@type":"ListItem","position":2,"name":"Solutions &#038; Services","item":"https:\/\/www.biotrial.com\/fr-ca\/solutions-services\/"},{"@type":"ListItem","position":3,"name":"Pr\u00e9clinique","item":"https:\/\/www.biotrial.com\/fr-ca\/solutions-services\/preclinique\/"},{"@type":"ListItem","position":4,"name":"Efficacit\u00e9"}]},{"@type":"WebSite","@id":"https:\/\/www.biotrial.com\/fr-ca\/#website","url":"https:\/\/www.biotrial.com\/fr-ca\/","name":"Biotrial","description":"Just another WordPress site","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/www.biotrial.com\/fr-ca\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"fr-CA"}]}},"_links":{"self":[{"href":"https:\/\/www.biotrial.com\/fr-ca\/wp-json\/wp\/v2\/pages\/7951","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.biotrial.com\/fr-ca\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.biotrial.com\/fr-ca\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.biotrial.com\/fr-ca\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.biotrial.com\/fr-ca\/wp-json\/wp\/v2\/comments?post=7951"}],"version-history":[{"count":52,"href":"https:\/\/www.biotrial.com\/fr-ca\/wp-json\/wp\/v2\/pages\/7951\/revisions"}],"predecessor-version":[{"id":10804,"href":"https:\/\/www.biotrial.com\/fr-ca\/wp-json\/wp\/v2\/pages\/7951\/revisions\/10804"}],"up":[{"embeddable":true,"href":"https:\/\/www.biotrial.com\/fr-ca\/wp-json\/wp\/v2\/pages\/7898"}],"wp:attachment":[{"href":"https:\/\/www.biotrial.com\/fr-ca\/wp-json\/wp\/v2\/media?parent=7951"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}