{"id":7952,"date":"2023-02-07T13:39:39","date_gmt":"2023-02-07T13:39:39","guid":{"rendered":"https:\/\/www.biotrial.com?page_id=7952"},"modified":"2026-05-06T07:58:03","modified_gmt":"2026-05-06T07:58:03","slug":"etudes-de-pk","status":"publish","type":"page","link":"https:\/\/www.biotrial.com\/fr-ca\/solutions-services\/service-preclinique\/etudes-de-pk\/","title":{"rendered":"\u00c9tudes de PK"},"content":{"rendered":"\n    <section class=\"acf anchors-depth-3 positionStickyElement\" id=\"\">\n        <div class=\"container\">\n            <div class=\"left\">\n                                    <a href=\"https:\/\/www.biotrial.com\/fr-ca\/solutions-services\/service-preclinique\/\" class=\"link return\">Retour<\/a>\n                            <\/div>\n            <div class=\"right\">\n                                    <a class=\"anchor\" href=\"#blockResources\">\n                        <span>Ressources<\/span>\n                    <\/a>\n                                    <a class=\"anchor\" href=\"#blockInformation\">\n                        <span>D\u00e9couvrir \u00e9galement<\/span>\n                    <\/a>\n                            <\/div>\n        <\/div>\n    <\/section>\n\n\n\n<section class=\"acf header-depth-3\" id=\"\">\n    <div class=\"container large\">\n                    <div class=\"container\">\n                <div class=\"content\">\n                                            <h1>\u00c9tudes de PK<\/h1>\n                                                                <p>Les \u00e9tudes de pharmacocin\u00e9tique (PK) sont essentielles en recherche pr\u00e9clinique. Elles d\u00e9crivent le comportement et le devenir d&#8217;un compos\u00e9 dans un organisme, fournissant des donn\u00e9es cruciales pour \u00e9valuer<strong> la s\u00e9curit\u00e9 <\/strong>et <strong>l&#8217;efficacit\u00e9<\/strong> d&#8217;un m\u00e9dicament lors des essais cliniques.<\/p>\n<p>Voici quelques avantages cl\u00e9s des \u00e9tudes PK en recherche pr\u00e9clinique :<\/p>\n<ul>\n<li><strong>Identifier les risques de toxicit\u00e9 :<\/strong>\u00a0Les \u00e9tudes PK peuvent r\u00e9v\u00e9ler des risques potentiels li\u00e9s \u00e0 un m\u00e9dicament, comme la toxicit\u00e9 ou les interactions m\u00e9dicamenteuses, contribuant \u00e0 la conception d&#8217;essais cliniques plus s\u00fbrs.<\/li>\n<li><strong>D\u00e9terminer le dosage optimal :<\/strong>\u00a0Les \u00e9tudes PK aident \u00e0 \u00e9tablir la posologie optimale d\u2019un m\u00e9dicament, comme la dose, la fr\u00e9quence et la voie d\u2019administration, donn\u00e9es cruciales pour obtenir l\u2019effet th\u00e9rapeutique souhait\u00e9 chez les patients.<\/li>\n<li><strong>Pr\u00e9dire la PK chez l\u2019humain :<\/strong>\u00a0Les \u00e9tudes PK chez l\u2019animal servent \u00e0 pr\u00e9voir le comportement d\u2019un m\u00e9dicament chez l\u2019homme, des donn\u00e9es utiles pour la conception et l\u2019interpr\u00e9tation des essais cliniques.<\/li>\n<\/ul>\n\n                                    <\/div>\n            <\/div>\n                            <picture>\n                <source type=\"image\/webp\"\n                    srcset=\"https:\/\/www.biotrial.com\/app\/uploads\/2023\/03\/istock-1288913722-1060x400.webp, https:\/\/www.biotrial.com\/app\/uploads\/2023\/03\/istock-1288913722-1060x400@2x.webp 2x\">\n                <source type=\"image\/jpeg\"\n                    srcset=\"https:\/\/www.biotrial.com\/app\/uploads\/2023\/03\/istock-1288913722-1060x400.jpg, https:\/\/www.biotrial.com\/app\/uploads\/2023\/03\/istock-1288913722-1060x400@2x.jpg 2x\">\n                <img decoding=\"async\" src=\"https:\/\/www.biotrial.com\/app\/uploads\/2023\/03\/istock-1288913722-1060x400.jpg\" alt=\"\"\n                    width=\"1060\" height=\"400\" loading=\"lazy\" \/>\n            <\/picture>\n            <\/div>\n<\/section>\n\n<section class=\"core-inline core-paragraph\" ><div class=\"container\">\n<p class=\"has-text-align-left has-gris-clair-2-background-color has-background\">Les \u00e9tudes <strong>PK <\/strong>sont vitales en recherche pr\u00e9clinique car elles fournissent des informations indispensables sur la <strong>s\u00e9curit\u00e9<\/strong>, <strong>l&#8217;efficacit\u00e9 <\/strong>et le <strong>dosage <\/strong>des nouveaux m\u00e9dicaments, <strong>cruciales pour un d\u00e9veloppement r\u00e9ussi<\/strong>.<\/p>\n<\/div><\/section>\n\n<div class=\"core core-columns\" ><div class=\"container\">\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-9d6595d7 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:60%\">\n<h2 class=\"wp-block-heading\">Exp\u00e9rience de Biotrial en PK<\/h2>\n\n\n\n<p>Notre <strong>\u00e9quipe d&#8217;experts <\/strong>en pharmacocin\u00e9tique m\u00e8ne des \u00e9tudes PK adapt\u00e9es \u00e0 vos besoins pour vous accompagner dans le d\u00e9veloppement de votre mol\u00e9cule.<\/p>\n\n\n\n<p>Nous offrons un large \u00e9ventail de services PK, incluant :<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Analyse non compartimentale<\/strong> : couramment utilis\u00e9e pour estimer des param\u00e8tres PK basiques tels que l&#8217;AUC, la Cmax et le Tmax.<\/li>\n\n\n\n<li><strong>Analyse compartimentale<\/strong> : utilis\u00e9e pour mod\u00e9liser la distribution et l&#8217;\u00e9limination des m\u00e9dicaments dans l&#8217;organisme \u00e0 l&#8217;aide de mod\u00e8les math\u00e9matiques, elle permet de comprendre le m\u00e9canisme d&#8217;action des m\u00e9dicaments.<\/li>\n\n\n\n<li><strong>Analyse pharmacocin\u00e9tique-pharmacodynamique (PK-PD)<\/strong> : elle \u00e9tablit une corr\u00e9lation entre les concentrations de m\u00e9dicaments et leurs effets, optimisant ainsi les r\u00e9gimes posologiques.<\/li>\n\n\n\n<li><strong>Pharmacocin\u00e9tique de population<\/strong> : pour mod\u00e9liser le comportement d&#8217;une mol\u00e9cule dans une population et identifier les facteurs influen\u00e7ant la PK.<\/li>\n<\/ul>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-vertically-aligned-center is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:40%\">\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-9d6595d7 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<figure class=\"wp-block-image size-full is-resized\"><picture><source srcset=\"https:\/\/www.biotrial.com\/app\/uploads\/2023\/03\/lqvkraz.webp\" type=\"image\/webp\" \/><img src=\"https:\/\/www.biotrial.com\/app\/uploads\/2023\/03\/lqvkraz.jpg\" width=\"660\"  height=\"436\" class=\"wp-image-2345\" alt=\"Biotrial-preclinical-Analysis\" ><\/picture><\/figure>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div><\/div>\n\n<section class=\"core core-media-text\" ><div class=\"container\">\n<div class=\"wp-block-media-text alignwide is-stacked-on-mobile is-vertically-aligned-center is-style-img-is-rounded\" style=\"grid-template-columns:43% auto\"><figure class=\"wp-block-media-text__media\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"683\" src=\"https:\/\/www.biotrial.com\/app\/uploads\/2023\/05\/2211023-biotrial-pdv-reportage-01-191-1-1024x683.jpg\" alt=\"Biotrial-preclinical-Analysis\" class=\"wp-image-5072 size-full\" srcset=\"https:\/\/www.biotrial.com\/app\/uploads\/2023\/05\/2211023-biotrial-pdv-reportage-01-191-1-1024x683.jpg 1024w, https:\/\/www.biotrial.com\/app\/uploads\/2023\/05\/2211023-biotrial-pdv-reportage-01-191-1-300x200.jpg 300w, https:\/\/www.biotrial.com\/app\/uploads\/2023\/05\/2211023-biotrial-pdv-reportage-01-191-1-768x512.jpg 768w, https:\/\/www.biotrial.com\/app\/uploads\/2023\/05\/2211023-biotrial-pdv-reportage-01-191-1-1536x1024.jpg 1536w, https:\/\/www.biotrial.com\/app\/uploads\/2023\/05\/2211023-biotrial-pdv-reportage-01-191-1-2048x1365.jpg 2048w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/figure><div class=\"wp-block-media-text__content\">\n<h2 class=\"wp-block-heading\"><br><br>Pharmacocin\u00e9tique In vivo <\/h2>\n\n\n\n<p>Biotrial est expert dans les services de pharmacocin\u00e9tique et de distribution tissulaire<em> in vivo<\/em>. Disposant d\u2019une exp\u00e9rience de plusieurs ann\u00e9es en \u00e9tudes<em> in vivo <\/em>chez les <strong>rongeurs <\/strong>et <strong>non-rongeurs<\/strong>, nous proposons divers services de pharmacocin\u00e9tique<em> in vivo<\/em>, comprenant :<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Modes d\u2019administration vari\u00e9s<\/strong> : voie orale, intraveineuse, sous-cutan\u00e9e, intramusculaire, intrap\u00e9riton\u00e9ale, etc.<\/li>\n\n\n\n<li><strong>\u00c9chantillons biologiques<\/strong> : plasma, sang, urine, liquide c\u00e9phalo-rachidien, bile et autres matrices biologiques.<\/li>\n\n\n\n<li><strong>Organes<\/strong> : exp\u00e9rimentation sur la distribution et le passage de la barri\u00e8re h\u00e9mato-enc\u00e9phalique (BHE), etc.<\/li>\n\n\n\n<li><strong>Excr\u00e9tion<\/strong> : analyse des f\u00e9ces, de l\u2019urine, de la bile, etc.<\/li>\n<\/ul>\n\n\n\n<p><\/p>\n\n\n\n<p><\/p>\n<\/div><\/div>\n<\/div><\/section>\n\n<section class=\"core-inline core-paragraph\" ><div class=\"container\">\n<p class=\"is-style-default\">Nous collaborons avec nos clients pour <strong>concevoir <\/strong>et <strong>r\u00e9aliser <\/strong>des \u00e9tudes pharmacocin\u00e9tiques in vivo r\u00e9pondant \u00e0 leurs besoins. Notre but est de les assister dans le d\u00e9veloppement de m\u00e9dicaments <strong>s\u00fbrs <\/strong>et <strong>efficaces <\/strong>en les accompagnant tout au long du processus de d\u00e9couverte et de d\u00e9veloppement du m\u00e9dicament.<\/p>\n<\/div><\/section>\n\n<div class=\"core core-columns\" ><div class=\"container\">\n<div class=\"wp-block-columns has-gris-clair-2-background-color has-background is-layout-flex wp-container-core-columns-is-layout-9d6595d7 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column has-noir-color has-text-color is-layout-flow wp-block-column-is-layout-flow\">\n<p class=\"has-noir-color has-text-color\">Nous offrons \u00e9galement d&#8217;autres services, tels que :<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Conception d\u2019\u00e9tudes et protocoles exp\u00e9rimentaux<\/li>\n\n\n\n<li>Analyse et interpr\u00e9tation des donn\u00e9es<\/li>\n\n\n\n<li>R\u00e9daction de rapports<\/li>\n\n\n\n<li>Support r\u00e9glementaire<\/li>\n<\/ul>\n\n\n\n<p class=\"has-noir-color has-text-color\">Nous nous engageons \u00e0 fournir des services de PK <strong>complets<\/strong>, <strong>de haute qualit\u00e9<\/strong>, et dans les d\u00e9lais impartis. Notre objectif est d&#8217;aider les sponsors \u00e0 d\u00e9velopper de nouveaux m\u00e9dicaments <strong>s\u00fbrs et efficaces <\/strong>en les soutenant tout au long du processus de d\u00e9veloppement des m\u00e9dicaments.<\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-column has-noir-color has-text-color is-layout-flow wp-block-column-is-layout-flow\">\n<p><strong><strong>Infrastructure pr\u00e9clinique de pointe<\/strong><\/strong><\/p>\n\n\n\n<p>Notre installation pr\u00e9clinique est accr\u00e9dit\u00e9e AAALAC et GLP, garantissant ainsi la conformit\u00e9 aux normes les plus \u00e9lev\u00e9es en mati\u00e8re de bien-\u00eatre animal et de rigueur scientifique. Nous disposons d&#8217;une vari\u00e9t\u00e9 d&#8217;\u00e9quipements pour soutenir nos \u00e9tudes PK, incluant :<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Laboratoire de bioanalyse<\/li>\n\n\n\n<li>Laboratoire de pharmacologie<\/li>\n\n\n\n<li>Installation pour h\u00e9berger les animaux<\/li>\n\n\n\n<li>Logiciels d&#8217;analyse de donn\u00e9es et de r\u00e9daction de rapports<\/li>\n<\/ul>\n<\/div>\n<\/div>\n<\/div><\/div>\n\n<section class=\"core-inline core-paragraph\" ><div class=\"container\">\n<p>Nous investissons constamment dans de <strong>nouvelles technologies<\/strong> et \u00e9quipements pour garantir que nos services PK restent \u00e0 la pointe.<\/p>\n<\/div><\/section>\n\n<div class=\"core core-columns\" ><div class=\"container\">\n<div class=\"wp-block-columns are-vertically-aligned-center is-layout-flex wp-container-core-columns-is-layout-9d6595d7 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-vertically-aligned-center is-layout-flow wp-block-column-is-layout-flow\">\n<figure class=\"wp-block-gallery has-nested-images columns-default is-cropped wp-block-gallery-1 is-layout-flex wp-block-gallery-is-layout-flex\">\n<figure class=\"wp-block-image size-large is-style-rounded\"><picture><source srcset=\"https:\/\/www.biotrial.com\/app\/uploads\/2023\/05\/2211023-biotrial-pdv-reportage-01-90-1024x683.webp\" type=\"image\/webp\" \/><img src=\"https:\/\/www.biotrial.com\/app\/uploads\/2023\/05\/2211023-biotrial-pdv-reportage-01-90-1024x683.jpg\" width=\"\"  height=\"\" class=\"wp-image-5309\" alt=\"Biotrial-clinical-pharmacy\" ><\/picture><\/figure>\n<\/figure>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-vertically-aligned-center is-layout-flow wp-block-column-is-layout-flow\">\n<h2 class=\"wp-block-heading has-text-align-left\">Activit\u00e9s compl\u00e9mentaires<\/h2>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Conseils sur la r\u00e9daction de synopsis, de protocoles et plan d&#8217;analyse statistique<\/li>\n\n\n\n<li>Analyses interm\u00e9diaires pour \u00e9tudes pr\u00e9cliniques et cliniques<\/li>\n\n\n\n<li>Estimations de taille d&#8217;\u00e9chantillons pour des \u00e9tudes de bio\u00e9quivalence et d&#8217;interaction m\u00e9dicamenteuse<\/li>\n\n\n\n<li>Production de TFLs (Tableaux, Figures, Listes)<\/li>\n\n\n\n<li>R\u00e9daction de la section PK pour des rapports d&#8217;\u00e9tudes pr\u00e9cliniques et cliniques ou des rapports PK d\u00e9di\u00e9s<\/li>\n<\/ul>\n<\/div>\n<\/div>\n<\/div><\/div>\n\n\n<section class=\"acf downloads\" id=\"blockResources\">\n    <div class=\"container\">\n                    <h2>Ressources<\/h2>\n                            <div class=\"contain-downloads\">\n                                                            <div class=\"download ask-for-personal-informations\" data-file=\"8022\" data-portal=\"144590169\" data-form=\"5b8373fb-7229-4db1-ad73-3c40512f9d3f\" style=\"background-color:#134052\">\n                            <span>PK et t\u00e9l\u00e9m\u00e9trie chez le cochon<\/span>\n                        <\/div>\n                                                                                <div class=\"download ask-for-personal-informations\" data-file=\"8023\" data-portal=\"144590169\" data-form=\"b82306a8-6b04-4790-b2e9-4a3107f8c34d\" style=\"background-color:#134052\">\n                            <span>\u00c9valuation de la sensibilit\u00e9 de l&#8217;essai de QT<\/span>\n                        <\/div>\n                                                <\/div>\n            <\/div>\n<\/section>\n<dialog class=\"downloadFile\" id=\"dialogDownloadFile_2\">\n    <div class=\"content\">\n        <div class=\"contain-text\">\n                                                <div class=\"text\" data-file=\"8022\" data-portal=\"144590169\" data-form=\"5b8373fb-7229-4db1-ad73-3c40512f9d3f\">\n                                                                            <strong class=\"title\">IMPROVEMENT OF ANIMAL WELFARE IN A MODEL OF  COMBINED PHARMACOKINETICS AND TELEMETRY IN THE MINIPIG :  HOW CAN REFINEMENT AND STUDY DESIGN REDUCE THE ANIMAL\u2019S STRESS ?<\/strong>\n                                                                    <\/div>\n                                                                <div class=\"text\" data-file=\"8023\" data-portal=\"144590169\" data-form=\"b82306a8-6b04-4790-b2e9-4a3107f8c34d\">\n                                                                            <strong class=\"title\">A JOINED INITIATIVE TO EVALUATE SENSITIVITY OF THE QT ASSAY WITH THE ICH E14\/S7B Q&#038;A BEST PRACTICE RECOMMENDATIONS<\/strong>\n                                                                            <div class=\"txt\"><p>In the context of the ongoing ICH E14\/S7B Q&amp;A process, it is critical to demonstrate the sensitivity of the in vivo QT assay to detect small QTc prolongation (i.e. \u226410 msec) of investigational drugs and conduct a concentration-QTc analysis to complement the standard \u201cby time point\u201d analysis approach and to mimick the clinical approaches. A collaborative cardiovascular study was designed in telemetered dogs using six QT-positive and one QT-negative reference drugs previously evaluated in healthy volunteers in the QT study conducted by Darpo et al. in 2015. As in the Darpo\u2019s trial, tested doses were chosen in order to reach exposure level inducing an increase of at least 10ms of the QTc interval. The results obtained with four drugs, dolasetron, moxifloxacin, dofetilide and levocetirizine, are presented here. Data for the other drugs are still being analysed.<\/p>\n<\/div>\n                            <span class=\"link disableReadExtractLink\">Fermer le r\u00e9sum\u00e9 et t\u00e9l\u00e9charger<\/span>\n                                            <\/div>\n                                        <span class=\"link readExtractLink\">Lire le r\u00e9sum\u00e9<\/span>\n        <\/div>\n        <div class=\"contain-form\">\n            <h2>T\u00e9l\u00e9chargement de nos posters scientifiques<\/h2>\n                            <p>Veuillez remplir les informations ci-dessous pour acc\u00e9der au t\u00e9l\u00e9chargement.<\/p>\n                        <div class=\"msg msgDownloadFile\"><\/div>\n            <div class=\"contain-form containFormDownloadFile\">\n\n                <div id=\"block_b653b742508ca0b578b64dd6ce796435_form\" class=\"hubspot-form\"><\/div>\n\n                <span class=\"description\">Toutes les informations marqu\u00e9es d&#8217;un &#8220;*&#8221; sont obligatoires.<\/span>\n                <div class=\"input\">\n                    <label for=\"lastnameDownloadFile\">Nom*<\/label>\n                    <div class=\"form-input person\">\n                        <input type=\"text\" class=\"lastnameDownloadFile\">\n                    <\/div>\n                <\/div>\n                <div class=\"input\">\n                    <label for=\"firstnameDownloadFile\">Pr\u00e9nom*<\/label>\n                    <div class=\"form-input person\">\n                        <input type=\"text\" class=\"firstnameDownloadFile\">\n                    <\/div>\n                <\/div>\n                <div class=\"input\">\n                    <label for=\"emailDownloadFile\">Email*<\/label>\n                    <div class=\"form-input mail\">\n                        <input type=\"email\" class=\"emailDownloadFile\">\n                    <\/div>\n                <\/div>\n                <div class=\"input\">\n                    <label for=\"companyDownloadFile\">Entreprise*<\/label>\n                    <div class=\"form-input travel\">\n                        <input type=\"text\" class=\"companyDownloadFile\">\n                    <\/div>\n                <\/div>\n                <div class=\"form-input large agree-terms\">\n                    <input type=\"checkbox\" class=\"agreeDownloadFile\" id=\"agreeDownloadFile_2\">\n                    <label for=\"agreeDownloadFile_2\" class=\"label-checkbox\">J&#8217;accepte que Biotrial utilise mes informations conform\u00e9ment \u00e0 leur <a href=\"https:\/\/www.biotrial.com\/fr-ca\/\/legal-notices\/\" target=\"_blank\">Politique de confidentialit\u00e9 et mentions l\u00e9gales<\/a>.<\/label>\n                <\/div>\n                <input type=\"hidden\" class=\"idDownloadFile\">\n                <div class=\"btn full white btnConfirmDownloadFile\">\n                    <span>T\u00e9l\u00e9charger le document<\/span>\n                <\/div>\n\n            <\/div>\n                \n        <\/div>\n    <\/div>\n    <span class=\"closeModal\">Fermer<\/span>\n<\/dialog>\n<script>\n    var downloadNonce = '8272a6f518';\n    var files = document.getElementsByClassName('ask-for-personal-informations');\n    for (var i = 0; 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