EEG Biomarker Portfolio

Biotrial’s Core Lab team is comprised of experts who specialize in supporting clinical sites across the globe with EEG measurements. This includes providing devices, training site staff to perform recordings, supporting the sites throughout the trial, and centrally analyzing the data captured.

EEG endpoints that can be centrally managed include:

Resting EEG

Seizure & Spike detection and
Qualitative neurologist review
Safety assessment (neurologist)
Spectral parameters (rel & abs
Brain maps
Spectral ratios
Source localization
Functional connectivity
Cognitive potentials
Auditory gating
Gamma evoked
Specifics upon request
P300 (oddball paradigm),
Auditory Steady State Response
Mismatch Negativity
Memory (LMT), Error Related
Negativity (flanker task)
P50, N100
Auditory Gating
Sustained Attention to Response
Sleep microstructure
Spectral analysis
Maintenance of Wakefulness Test
Sleep staging (ASSM 2007 or
Apnea, Hypopnea, Arousals,
Periodic movements, etc.
Spindle analysis: Count, Density,
Position, Frequency, Amplitude,
Duration, Power, etc…
Resting EEG
Sleep scoring
Spectral parameters
Auditory Steady State Response
Seizure count

    Examples of recording paradigms:

    • Standard recording protocol of 20 to 40 minutes, including photic stimulation & hyperpnoea
    • A long-duration continuous recording lasting up to 48 hours. This is the gold standard for detecting epileptogenic activity

Quantitative EEG (qEEG)

Biotrial offers a comprehensive range of qEEG services to support our clients in the development of new drugs and treatments for neurological disorders. qEEG is a non-invasive method that is used to measure the electrical activity of the brain. It can be used to assess the impact of a compound on brain function by measuring changes in brain waves in different frequency bands.

Biotrial’s qEEG services help our clients to:

  • Establish proof of mechanism: identify the specific brain mechanisms that are affected by a compound. This information can be used to validate the drug target and to guide the development of new and more effective drugs and treatments.
  • Define the compound’s EEG signature:  create a unique EEG signature for a compound. This signature can be used to track the compound’s effects on brain function over time and to compare it to the effects of other known drugs.
  • Compare to the action of existing known drugs: compare the EEG signature of a new compound to the EEG signatures of existing known drugs. This information can be used to understand how the new compound works and to predict its potential therapeutic effects.
  • Understand the physiological effects of their compound (drowsiness, cognition, etc.): assess the physiological effects of a compound, such as drowsiness and cognition. This information can be used to design safe and effective clinical trials and to develop new and innovative drugs and treatments.

Example: Characterization of the CNS Effects of Benzodiazepines

Time-frequency representation of Diazepam effect on rodents and reversal by Flumazenil.


Cross-over study on 20 healthy volunteers administered with Lorazepam (brain mapping representation).

2211023 Biotrial Pdv Reportage 01 64

Polysomnography (PSG)

PSG recordings can be used to investigate a compound’s effect on participants’ sleep. These recordings are performed overnight within a clinical setting and allow to determine a participants hypnogram as well as a full set of sleep parameters such as sleep latency, total sleep time, sleep efficiency, time per stage, WASO, etc…

In addition to EEG we record EOG, EMG, ECG and, for specific sleep apnea investigations it is also required to record breathing.

Clinical Site Support & Equipment

Biotrial’s Core Lab offers state-of-the-art equipment and continuous staff support specifically designed for clinical trials.

  • Global shipment of EEG/PSG devices for collection of data
  • Site training and 24/7 support for worldwide clinical sites
  • Immediate replacement of any defective equipment
  • Continuous quality monitoring of Data recordings with feedback to study sites

Biotrial’s fullyvalidated system ensures high-quality EEG recordings. The study-specific kits are user-friendly and allow for quick set-up at any clinical site (CPU or hospital) involved in a clinical trial. Our equipment supports standard EEG as well as advanced EEG-based assessments, such as PSG or ERP, in addition to 24-hour (or longer) ambulatory recordings.

EEG Analysis & Reports

EEG recordings are processed by our expert signal processing team. The Biotrial Core Lab uses validated signal processing tools and medical expertise to implement study data analyses:

  • Qualitative reviews by board-certified neurologists
  • qEEG: spectral analysis of the EEG recording, brain maps to provide a graphic representation of results
  • ERP (auditory or visual event-related potentials): brain mapping and graphical representations
  • Polysomnography (sleep EEG): sleep scoring, spectral analysis, spindle analysis
  • Exploratory analysis: study specific algorithm implementation

In order to ease the understanding and interpretation of the EEG signal and results, our team has developed a series of tools used to provide graphic, easy-to-grasp representations of these results. These are reported back to the sponsor team at regular times during a project.

Data Management, Statistical Analysis & Report Writing

All activities are covered by Biotrial SOPs, guaranteeing data quality, process efficiency & compliance.

  • Custom-made database set up and sponsor-specific data transfer protocols
  • Statisticians & Medical Writers with extensive EEG experience

Consulting & Design Services

  • Biotrial Experts can help you select the optimal EEG modality and the relevant assessment method for your project
  • Animal EEG data can easily be generated in our preclinical facilities to support sponsor development strategies
  • We offer interpretation of data and advice on the overall development plan for your compound.
Biotrial Core Lab Qeeg

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