CNS Testing

With over 35 years of experience in conducting clinical trials. We offer a comprehensive suite of services, ranging from preclinical models to advanced clinical trials, to support sponsors in the development of new drugs and treatments for patients with neurological disorders.

Our CNS testing battery encompasses a variety of components that facilitate the measurement of cognitive function, motor function, and subjective elements such as:

  • Memory
  • Attention
  • Vigilance
  • Balance
  • Oculography
  • Subjective element

Our tools are designed to be flexible and can seamlessly integrate sponsor-specific tests & questionnaires.


The CNS tests used by Biotrial enable sponsors to gather pertinent Pharmacodynamic (PD) data. Often, these data complement the clinical observations made by site staff and provide deeper insight into drug effects.

PEPSY Cognitive Testing

PEPSY is a cutting-edge cognitive testing platform developed by our expert team, offering a wide range of services to support clinical trials in neuroscience across various therapeutic areas.

PEPSY Services

  • Consulting services to help you design your clinical trial protocol and select the appropriate cognitive tests.
  • Equipment Shipment and Installation Worldwide ensures you have the tools you need to conduct your trial smoothly and efficiently.
  • Dedicated project managers to oversee your clinical trial and ensure that it stays on track and meets all of your requirements.
  • Staff Training on how to use its equipment and software so that they can collect high-quality data.
  • 24/7 Support Hotline
  • Data Collection and Continuous Quality Monitoring
  • Data Management and Transfer: manage your data securely and transfer it to you in a format that is easy to analyze.
  • Statistical Analysis and Expert Report

Body Sway – Posturography

Posturography, a cornerstone in our suite of services, is an objective, sensitive, and reliable method for assessing body sway and vigilance. This non-invasive method can be used to evaluate the effects of drugs and other interventions on balance and coordination, crucial aspects in the study of neurological disorders


Biotrial utilizes a dedicated platform to perform posturography testing. Equipped with sensors that measure the participant’s body movements, the platform provides valuable data, including:

  • Center of pressure (CoP)
  • Sway area
  • Sway velocity
  • Reaction time
  • Alertness

Posturography is a valuable tool for clinical trials, particularly in studies of drugs targeting neurological disorders or exploring potential interactions with substances like alcohol.


Oculography Measures

Oculography, a key component of our neuroscience services, is the scientific study of eye movements. It plays a pivotal role in assessing eye movement disorders, neurological function, and cognitive function.

Various oculography measures are employed to assess different aspects of eye movement, including:

  • Saccadic Eye Movement
  • Smooth Pursuit
  • Fixation
  • Nystagmus
  • Pupillometry
  • Eye-tracking

Our state-of-the-art devices cater to different oculography measures, ensuring precision and reliability in data collection. High-frequency sampling is employed when investigating saccadic eye movements, pursuit, or nystagmus, requiring specialized hardware.


Attention & Psychomotor Performance

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Simple Reaction Time (SRT)

  • Motor response to a simple visual stimulus

Choice Reaction time (CRT)

  • Motor response to a complex visual stimulus

Tracking test (TT)

  • Hand-eye coordination and delays in visual motor response

Rapid Visual Information Processing (RVIP)

  • Sustained attention and working memory

Digit Vigilance (DV)

  • Sustained attention

Divided Attention (DA)

  • Capacity to divide and allocate attention

Body Sway (BS)

  • Effects of drug on body sway and vigilance, recorded using a force-platform

Saccadic Eye Movement (SEM)

  • Analysis of eye movement to detect changes in attention and sedation


Biotrial Core Lab Memory

Memory, a critical aspect of cognitive function, is a focus of our services. We conduct a variety of tests to assess different aspects of memory, such as short-term memory, long-term memory, and working memory. Common memory tests include:

  • Learning memory task (LMT): assess the ability to learn and retain new information.
  • Numeric Working Memory (NWM): assesses the ability to hold and manipulate numerical information in short-term memory.
  • Spatial Working Memory (SWM): assesses the ability to hold and manipulate spatial information in short-term memory.

These tests contribute to a comprehensive understanding of the cognitive effects of drugs under study.

  • Bond & Lader Visual Analog Scale (VAS): assess anxiety and sedation.
  • Addiction Research Center Inventory (ARCI): evaluate the severity of alcohol dependence.
  • Leeds Sleep Evaluation Questionnaire (LSEQ): gauge sleep quality.
  • Profile Of Mood State (POMS): assess mood states.
  • Discontinuation Emergent Signs & Symptoms (DESS): evaluate the presence and severity of withdrawal symptoms.
  • Pain VAS: measure pain intensity.
  • Columbia Suicide Severity Rating Scale (C-SSRS): assesses the severity of suicidal ideation and behavior.
  • Appetite and Satiety VAS: gauge appetite and satiety.

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