Drug Efficacy in preclinical studies

Models used for studying diseases must exhibit pathological similarities closely resembling the conditions observed in humans. Experimental animal models are therefore useful for a better understanding of disease mechanisms and for evaluating the therapeutic efficacy of new and emerging drugs.

  • Validated models for a variety of therapeutic areas, including oncology, CNS, cardiovascular and hemostasis, respiratory, and renal and gastrointestinal disorders.
  • Expertise in a wide range of efficacy assays and methodologies.
  • A dedicated team of scientists who work closely with you at all stages of the drug discovery and development process to select the best approach for your study.

We are committed to providing high-quality data and reports that help you to make informed decisions about the development of your drugs.


Our dedicated team works closely with you through all stages of the drug discovery and development process to select the best approach for your efficacy study.


Cancer is a vast group of diseases that can manifest in virtually any organ or tissue within the body and which has the potential to metastasize to other regions. It is the second most prevalent cause of mortality worldwide, driving significant research efforts and pioneering innovative oncology therapeutics.

Biotrial is a global CRO with extensive experience in both in vitro assays and in vivo models for evaluating the efficacy of new oncology drugs. 

We work closely with biotech and pharmaceutical sponsors to design and execute the most appropriate preclinical oncology efficacy studies for their specific needs. Our goal is to help our sponsors develop safe and effective new oncology drugs that improve the lives of patients around the world.

Cancer Cells Vis
Biotrial Nonclinical Drug Efficacy Cns


Biotrial provides a large range of simple and complex models for CNS efficacy studies and in setting up new models according to specific scientific requirements and project objectives.

We offer validation data & scientific guarantee for all of our CNS efficacy models. And, as a full-service translational CRO, we can help you to bridge the gap between preclinical and Phase I-IV clinical trials.

  • Validation Data & Scientific Guarantee
  • Translational service CRO
  • Complementary techniques

With experienced and dedicated neurosciences experts, Biotrial’s CNS efficacy includes validated models for the following:

  • Psychiatry: Anxiety, Depression, Panic Disorder
  • Schizophrenia: Positive, Negative Symptoms & Cognitive Dysfunction
  • Neurological Disorders: Alzheimer’s Disease, Parkinson’s Disease
  • Cognition
  • EEG

Cardiovascular & Hemostasis

Cardiovascular diseases are disorders of the heart and blood vessels and are still the leading cause of death globally. Extensive research in the field always leads to new and innovative solutions to be evaluated.

For decades we have conducted cardiac and hemodynamic studies in rodents and large animals. We propose cardiovascular pathophysiological models of arrhythmias, heart failure, and thrombosis, and possess a wealth of experience in performing cardiovascular telemetry studies across all species.

We offer a comprehensive range of preclinical cardiovascular efficacy testing services, including:

  • Cardiac safety pharmacology studies to assess the potential cardiotoxicity of new drugs.
  • Cardiovascular pathophysiology models to study the effects of drugs on specific cardiovascular diseases, such as arrhythmias, heart failure, and thrombosis.
  • Cardiovascular telemetry studies to monitor the cardiovascular effects of drugs in conscious animals.
Red Blood Cells Flowing Through The Blood Stream
Biotrial Nonclinical Follow Up Cardiovascular


Biotrial Nonclinical Drug Efficacy Respiratory

Respiratory diseases affect the airways and other structures of the lungs. At Biotrial our preclinical unit strives to Evaluate the safety and efficacy of new respiratory disease drugs and therapies and study the disease process in more detail. We are also equipped with whole-body Plethysmography and have validated rodent models for the evaluation of drugs intended to to treat respiratory pathologies, including:

  • Lung Edema
  • Airways Inflammation
  • COPD

We are also equipped with whole body Plethysmography for the evaluation of Respiratory Function in conscious rodents

Renal & Gastrointestinal 

The kidneys filter waste and excess fluids from the blood, which is then excreted in the urine. Kidney failure describes the gradual loss of kidney function that may lead to high levels of fluid, electrolytes, and waste in the body.

Gastrointestinal (GI) diseases affect the GI tract from the mouth to the anus. Many factors can upset the GI tract, leading to various structural and/or functional pathologies and our research helps us to understand the causes and mechanisms of diseases affecting these organ systems, and to help sponsors develop new and improved human treatments.

Biotrial is a preferred partner for Biotech and Pharmaceutical companies, particularly experienced in preclinical renal and gastrointestinal efficacy studies and experience in performing a variety of renal and GI function tests. We offer a variety of renal and GI pathophysiological models, including:

Biotrial Nonclinical Follow Up Respiratory
Human Digestive System Anatomy

GI Disease Models

  • Inflammatory bowel disease (IBD)
  • Perianal Fistula

Gastrointestinal  Function

  • GI motility
  • Gastric emptying

Our Preclinical Team

Biotrial’s preclinical team has extensive experience and expertise in the efficacy assessment of new drugs. The team is composed of highly qualified scientists with a deep understanding of the preclinical efficacy testing process. Our experts are committed to providing high-quality, comprehensive, and timely efficacy assessment services to the sponsors. Our dedicated team works closely with you through all stages of the drug discovery and development process to select the best approach for your efficacy study.



Oncology Preclinical posters
Sleep Spindles: EEG Telemetry Recording
Respiratory scientific publications

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