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PK studies

Our highly experienced pharmacokineticists perform a variety of pharmacokinetic analyses, including non-compartmental and compartmental analysis, and PK/PD analysis.

All design analysis and reporting are based on ICH guidelines, following your needs and Biotrial’s SOPs

Understand Drug Exposure
Determine Appropriate Dosage
Manage Changes in Dosage Requirements
Estimate Elimination and Absorption Rates
Recognize Intra-Subject and Inter-Subject Variability
Understanding Drug Concentration-Effect Relationships

In Vivo Pharmacokinetics

Biotrial provides in vivo pharmacokinetic research and tissue distribution research services.

Animals: rodent and non-rodent
Method of administration: Intravascular/Subcutaneous/Intramuscular/Intraperitoneal/Per Os, etc.
Biological samples: Plasma, whole blood, Cerebro Spinal Fluid (CSF), bile, and other fluid biological matrices.
Organs: Distribution experiment and Blood Brain barrier (BBB) transmission experiment of the brain, Cerebro-Spinal Fluid, liver, heart, and kidney etc.
Excretion: Feces, urine, bile, etc.

What kind of analysis ?

For preclinical and clinical studies:

Non-compartmental analysis (NCA)

Experience with numerous clinical designs: SAD/MAD, Hepatic impairment, DDI, Food-effect, Bioequivalence, Patient studies with sparse sampling, Biosimilars, and more…
Knowledge of PK and statistical analysis guidelines

Compartmental analysis (CA) for mechanism understanding (ex: bi-phasic profiles)