Respiratory Pharmacology

Biotrial specializes in the development of new models together with the sponsor. Please do not hesitate to contact us to discuss your needs

Lung Edema

  • Non-sensitized animals (Histamine, Substance P, 5-HT)
  • Ovalbumin-sensitized animals

Airways Inflammation

  • Acute lung inflammation induced by LPS (ARDS) or cigarette smoke (COPD)
  • Measurement of proinflammatory cytokines (bronchoalveolar lavage, lung tissue)
  • Elastase-induced lung emphysema
  • Bleomycin-induced pulmonary fibrosis

  • Antigen-induced allergic response (Ovalbumin-sensitized animals)
  • BAL (eosinophils, neutrophils, etc.), immediate bronchoconstriction, bronchial hyperresponsiveness
  • Pro-allergenic potential

Respiratory Function by Whole Body Plethysmography

  • Bronchospasm
  • Citric acid-induced cough
  • Sleep apneas

Scientific Publications